Taking Tadalista 20mg (tadalafil) with alcohol is generally not recommended because both substances can affect blood pressure and circulation. Tadalista 20 helps improve erectile function by relaxing blood vessels, but alcohol is also a vasodilator, meaning it widens blood vessels. When combined, this effect may lead to a significant drop in blood pressure, causing dizziness, fainting, headache, or even heart complications in some individuals. Additionally, alcohol can reduce sexual performance and interfere with the effectiveness of tadalafil, making the medication less reliable. While moderate drinking (like a glass of wine) may not cause severe issues for healthy individuals, excessive alcohol consumption can increase side effects such as flushing, rapid heartbeat, and impaired judgment. For best results and safety, it is advisable to limit or avoid alcohol when taking Tadalista 20.